Rhea Biochemical Reactions API

Rhea Biochemical Reactions API

Rhea (rhea-db.org), maintained by the SIB Swiss Institute of Bioinformatics, provides a keyless REST API returning TSV for expert-curated biochemical and transport reactions (ChEBI-based equations, enzyme links). A live reaction query confirms the service (RHEA:10000).

Coverage

Expert-curated biochemical and transport reactions (ChEBI-based equations, links to enzymes), confirmed live today via a reaction query (RHEA:10000). History start: Not stated. Update frequency: the update-frequency page says, "From January 2020, Rhea is updated every eight weeks (six releases / year)."

Verdict

Keyless REST API returning TSV for Rhea's expert-curated biochemical and transport reactions (ChEBI-based equations, enzyme links), from the SIB Swiss Institute of Bioinformatics (confirmed live today via a reaction query, RHEA:10000). Licensed CC-BY-4.0: "Rhea is available under the Creative Commons Attribution 4.0 International (CC BY 4.0) License. This means that you are free to copy, distribute, display and make commercial use of the database in all legislations, provided you credit Rhea." The REST API help page asks: "Please consider to provide a contact email address as part of the User-Agent header that your programs set. This will allow us to contact you in case of problems (see our privacy notice)." Rate limits: Not stated. Signal Lab links only.